Do not sacrifice everything in the name of petty freedoms. The Protheans tried to fight and they were utterly destroyed. Trillions dead. But what if they had bowed before the invaders?
Would the protheans still exist?
"Can guess captured Protheans lost intelligence over several, cloned, generations. Cybernetic augmentation widespread afterward as Protheans failed, Reapers added Tech to compensate. Mental capacity almost gone. Replaced by overworked sensory input transfers, transmitting data to masters. No glands, replaced by tech! No digestive system, replaced by tech! No soul! Replaced by tech!
"Whatever they were, gone forever.
"Understand now? No art, no culture, closer to husks than slaves, tools for Reapers.
"Protheans dead. Collectors just… final insult." — Mordin Solus, Mass Effect 2